Thursday, February 18, 2016

Spanish perspective: Development of vaccines in the fight against Ebola

Last year in Spain, after the case of Teresa Romero in 2014 and the use, in that time, of an experimental vaccine combining the antibodies extracted from a Spanish survivor of the disease, Paciencia Melgar, who caught the disease while helping in a NGO in Africa, and an antiviral called favipiravir; the development of vaccines against the Ebola took a lot of importance in the medical investigation of Spain. The latest news date from 4 months ago, in which the hospital Carlos III in Madrid took and are still part of an experimental vaccine investigation, called the VSV-ZEBOV (La Nueva España, 2016)

This vaccine was produced initially in collaboration with Germany and Canada, and works with antibodies of animals which were supplied with a dose of the virus, and the objective is to make the virus detectable for the body to neutralize it completely. Like this the virus would not be able to supply the protein harmful for our body. The objective of the researches that are being done is to test their effectiveness in humans (is not very common to produce the antibodies from animals instead from human cells) and what would be their secondary effects. (Prats, J. 2014)

Although it has been speculated that that, for now, it efficiency has been of nearly a 100%, there has been, especially from the clinical team of the hospital Carlos III, regarding the problem of poor security measurements used to handle the disease. They claim that to treat this kind of extreme contagious disease, the level of security on their equipment should be of Level 4, while they are only permitted to use Level 2 suits. (EL PAÍS, 2014)
  














The difference, as it is shown with the image, is quite important. While the Level 4 has their own autonomous respirator and plastic, impermeable and airtight suits to avoid any possible contact with the disease at any time, the Level 2 suits is only supplied with a mask which could filter in the worst scenario the virus and one layer only suits which can be insufficient to stop the virus to make contact with their bodies. (EL PAÍS, 2014)

BIBLIOGRAPHY:
-          La Nueva España, (2016). La vacuna experimental del ébola se probará en España. Retrieved the 18th of February 2016, from http://www.lne.es/vida-y-estilo/salud/2015/08/05/vacuna-experimental-ebola-probara-espana/1796394.html
-          Prats, J. (2014). ¿En qué consiste el tratamiento experimental contra el ébola? El País (Edición España). Retrieved the 18th of February 2016, from http://sociedad.elpais.com/sociedad/2014/08/07/actualidad/1407408112_524579.html

-          EL PAÍS, (2014). El ébola, en dos minutos. Retrieved 18 February 2016, from http://politica.elpais.com/politica/2014/10/08/actualidad/1412790640_746525.html?id_externo_promo=microseo

Sunday, February 14, 2016

American Perspective: The Approach to Ebola

Ebola is a deadly disease caused from the Ebola virus species.  It can cause harmful effects to humans and primates.  Ebola is spread by saliva, blood, objects that contain bodily fluids (saliva,blood,etc), animal bites, and touching an infected surface.  In America, there has been 10 cases of Ebola patients.  8 of the patients recovered, and 2 of them died.  Ebola is found in Africa and was spread to other countries through people that were effected by the disease and traveled back to a different country. 

Sadly, there is NO FDA approved vaccine to treat ebola.  It is not likely to come in contact with this disease (only 10 cases in the U.S.), but being prepared for the worst is very wise.  Always practice good hygiene by washing your hands with soap or using an alcoholic base hand sanitizer to kill bacteria.  In general do not come in contact with a person with Ebola or their bodily fluids. 

The United States did not create any advanced technology nor any vaccines to try to treat ebola.  Instead they caught the disease quickly in most of the patients and did simple treatments to help them get rid of ebola.  It is easy to find out if a patient has ebola by their treatments.  A patient would usually have severe headaches, muscle pain, weakness, fatigue, diarrhea, vomiting, stomach pain, and unexplained hemorrhage.  Although the U.S. did not create any sort of new technology they very well had advanced technology.  Basically, what the United States do was immediately isolate the patient into his own house.  They will continuosly keep him isolated and try their best to avoid touching the patients.  This may be very hard to do when trying to keep track of how their bodies are doing (heartrate, x-rays, etc.).  To track these things doctors use an advanced technology called telehealth.  Telehealth in summary is advancing technology that allows you to record data of the patient without touching them.  Overall, Ebola was handeld extremely well in the United States.

Sources
http://www.cdc.gov/vhf/ebola/healthcare-us/evaluating-patients/think-ebola.html
http://www.cdc.gov/vhf/ebola/treatment/index.html
http://news.nationalgeographic.com/news/2014/11/141106-science-ebola-cure-medicine-health-africa-disease-technology/

American Perspective: Cancer and Strides Towards Cures

Cancer, as defined by the American Cancer Society, is a word used to describe more than 100 diseases. Cancer is not just one disease, but an umbrella term which can be used to cover an enormous amount of cases wherein body cells uncontrollably divide and grow, into primary or secondary tumors which may metastasize, stay in the blood stream, or otherwise. In IB Biology, we've learned that these cases arise because of one's living environment (influences epigenetics), predisposition for oncogene mutations, or simply because of mutations in DNA sequences -- random or because of certain chemicals, such as mutagens.
If one would like to read more general information about cancer and its different forms, the links below are very informative.

http://www.cancer.gov/about-cancer/what-is-cancer
http://www.cancer.org/cancer/cancerbasics/index
http://www.cancer.net/cancer-types 

Cancer is omnipresent in our world, and affects the lives of millions every day. In the United States alone, the National Cancer Institute estimates that about 8 million Americans have a history of cancer -- this includes both those who are considered cured and those who still have evidence of cancer today. As the Centers for Disease Control and Prevention (CDC)  website states, cancer is the second leading cause of death in the US. For this reason, and for many others, a great deal of effort has been put into finding both treatments and cures for all the various types of cancer, and many strides have been made toward these goals with the help of new technology.

Specifically in 2015, the American Society of Clinical Oncology (ASCO) made serious progress in terms of both cancer prevention and treatment. Highlighted within the "Clinical Cancer Advances 2016" annual ASCO report on progress in cancer research was the ASCO's Advance of the Year, cancer immunotherapy. This treatment involves manipulating the body's immune system to attack cancer wherever it is in the body, and has worked incredibly well for cancers such as advanced melanoma and lung cancer. This therapy, as explained in the report, is a dual strategy plan: "the first involves unleashing the body’s natural immune response to cancer, and the second helps the immune system find and destroy cancer cells".

This first strategy involves the use of immune checkpoint inhibitors, which release "tumor-induced brakes" in the immune system which allow it to attack and stop malignant tumors from growing, while allowing immune checkpoints, molecules used by the body to control immune responses, to minimize the damage of the affected tissue. The ASCO states that by late 2014, “three life-extending checkpoint inhibitor immunotherapies were FDA approved for the treatment of advanced melanoma” (ipilimumab, nivolumab, and pembrolizumab), and that “these new drugs have surpassed the efficacy of traditional melanoma treatments” (Dizon et. al). There is even evidence to suggest that combining different immunotherapies could further benefit the patients for whom single immunotherapies have worked, and also those who have not been exposed as of yet, despite the fact that some patients had adverse effects. 

In the case of lung cancer, which as the ASCO states is the leading cause of cancer-related deaths world-wide, immune checkpoint inhibitors have also been proven to be beneficial. Recent clinical trials have shown that “compared with standard second-line chemotherapy, nivolumab”, one of the 3 checkpoint inhibitors, “significantly improved the median overall survival (9 months v 6 months), nearly doubling the 1-year survival rate (42% v 24%)” (Dizon et. al). To learn more about the immunotherapy developments made by the ASCO, the links below explain the therapies in extensive detail.
  • http://jco.ascopubs.org/content/early/2016/02/01/JCO.2015.65.8427.full
  • http://www.cancerprogress.net/cca/advances-cancer-treatment

Both Melanoma and lung cancer are considered incurable as of yet, but these immunotherapy treatments which have been and are currently being further developed are amazing steps towards finding cures for cancer in its different forms. The development of these new drugs and technologies has enabled scientists and oncologists not only to learn more about the cancers they are dealing with, but also to make great strides towards finding cures and more efficient and helpful treatments for different types of cancers.



Sources
American Cancer Society. "What Is Cancer? A Guide for Patients and Families." What Is Cancer? American Cancer Society, 8 Dec. 2015. Web. 14 Feb. 2016. <http://www.cancer.org/cancer/cancerbasics/what-is-cancer>.

Centers for Disease Control and Prevention. "Statistics for Different Kinds of Cancer." CDC - Cancer Prevention and Control. Centers for Disease Control and Prevention, 20 Aug. 2015. Web. 14 Feb. 2016. <http://www.cdc.gov/cancer/dcpc/data/types.htm>.


Dizon, D. S., L. Krilov, E. Cohen, T. Gangadhar, P. A. Ganz, T. A. Hensing, S. Hunger, S. S. Krishnamurthi, A. B. Lassman, M. J. Markham, E. Mayer, M. Neuss, S. K. Pal, L. C. Richardson, R. Schilsky, G. K. Schwartz, D. R. Spriggs, M. A. Villalona-Calero, G. Villani, and G. Masters. "Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology." Journal of Clinical Oncology (2016): n. pag. Clinical Cancer Advances 2016. American Society of Clinical Oncology, 4 Feb. 2016. Web. 14 Feb. 2016. <http://jco.ascopubs.org/content/early/2016/02/01/JCO.2015.65.8427.full>.